Chromosomal abnormalities occur in approximately 1 in 150 live births with Down syndrome being the most common with a prevalence of 1 in 800. Down syndrome is the most common aneuploidy seen in live births. ![]() The purpose of prenatal screening for aneuploidy is to identify women who are at an increased risk for the most common aneuploidies. doi: 10.Prenatal screening for aneuploidy has evolved dramatically over a short period of time. Epidemiology of Gestational Diabetes Mellitus According to IADPSG/WHO 2013 Criteria Among Obese Pregnant Women in Europe. doi: 10.2337/dc09-1848Įgan AM, Vellinga A, Harreiter J, Simmons D, Desoye G, Corcoy R, et al. International Association of Diabetes and Pregnancy Study Groups Recommendations on the Diagnosis and Classification of Hyperglycemia in Pregnancy. Metzger BE, Gabbe SG, Persson B, Buchanan TA, Catalano PA, et al. International Association of Diabetes and Pregnancy Study Groups Consensus Panel. Prevalence Trends Diabetes Among Adults United States, 1988–2012. Menke A, Casagrande S, Geiss L, Cowie CC. Prevalence and Control of Diabetes in Chinese Adults. Xu Y, Wang L, He J, Bi Y, Li M, Wang T, et al. Prevalence of Gestational Diabetes Mellitus in Mainland China: A Systematic Review and Meta-Analysis. Hyperglycaemia oral glucose tolerance pregnancy risk factor screening strategy.Ĭopyright © 2022 Xu, Wei, Zhang, Duan, Wang and Huang. This study was registered in the Chinese Clinical Trial Registry (no. We recommend sequential screening in early and middle pregnancy for high-risk pregnant women with maternal age ≥35 years or pre-pregnancy BMI ≥23 kg/m 2, and in early, middle, and late pregnancy for high-risk pregnant women with a previous history of GDM. The weight gain during pregnancy was lower in the experimental early-HIP, middle-HIP, and control NBG subgroups. The gestational age at delivery was significantly earlier in the experimental subgroup with early-HIP than in the experimental and control subgroups with normal blood glucose (NBG). No significant differences in perinatal clinical data were observed between the experimental and control groups. Previous GDM (OR=8.713, P=0.002) was a risk factor for HIP diagnosis in late pregnancy. Multivariate logistic regression analysis revealed that previous gestational diabetes mellitus (GDM) (odds ratio, OR=9.676, P<0.001), pre-pregnancy body mass index (BMI) ≥23 kg/m 2 (OR=4.273, P<0.001), and maternal age ≥35 years (OR=2.377, P=0.010) were risk factors for HIP diagnosis in early pregnancy. The total HIP diagnosis rate was significantly higher in the experimental group (53.44% vs. In the experimental group, HIP was diagnosed in 29.51% (90/305), 13.44% (41/305), and 10.49% (32/305) of patient in early, middle, and late pregnancy, respectively. The general conditions, HIP diagnosis, and perinatal outcomes of the two groups were compared. ![]() Pregnant women underwent a 75-g OGTT in early (<20 weeks), middle (24-28 weeks), and late pregnancy (32-34 weeks) in the experimental group and only in middle pregnancy in the control group. This prospective study aimed to explore a screening strategy for women at high risk for HIP.Ī total of 610 pregnant women were divided into experimental (n=305) and control (n=305) groups. However, the screening and diagnostic strategies for pregnant women with risk factors for HIP are not set. ![]() Hyperglycaemia in pregnancy (HIP) is closely associated with short- and long-term adverse fetal and maternal outcomes.
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